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Target therapy represents a significant step forward in the treatment of malignant tumors. These therapies typically address to molecular pathways essential for the growth and replication of neoplastic cells.
Regardless of the cause of a duodenal perforation, operative treatment remains a fundamental therapeutic choice. The endoscopic closure of leaks is helpful only for fresh defects without an accompanying infection and is limited by the size of the defect.
Imaging tests such as Chest X-Ray (CXR) and Lung Ultrasound (LUS), and blood biomarkers like C-reactive protein and procalcitonin have demonstrated its role for Bacterial Pneumonia (BP) diagnosis. However, the implementation of novel biomarkers such as Lung Shear-Wave Elastograph.
Accurately estimating inpatient billing costs during admission is important for financial planning in healthcare. Traditional methods have limitations in capturing true cost; hence, data-driven approaches are needed to improve hospital cost estimation in complex and dynamic environments.
A 72-year-old patient, known in her personal medical history with essential hypertension, chronic autoimmune thyroiditis and hypothyroidism, undergoing chronic treatment with Euthyrox, shows specific symptoms of hyperthyroidism (palpitations, profuse sweating).
The ugly rise in rape cases in Nigeria caused by persistent use of stimulants commonly referred to as 'skunchies and Rohypnol posed a great challenge for health professionals and drug regulatory authorities. We report two cases of illicit use of controlled or banned substances in the preparation of 'zobo' artisanal beverages in some parts of Nigeria and consumed by some youths to be 'high'.
An incidental finding was found in a young football player with no previous disease after a blow in lumbar area. After a proper treatment of a complication (hematuria) and thanks to an image diagnosis, we could diagnose a very common genetic cause of renal failure worldwide but not very usual in Emergency Department and Primary Care Medecine: Autosomal Dominan Polycystic Kidney Disease.
The impact of the COVID-19 pandemic caused by SARS-CoV-2 on global public health, emphasizing its severity and the efforts made to enhance diagnostic practices and clinical management. Chest Computed Tomography (CT) has been widely used to assess complications caused by the virus, particularly in patients coinfected with HIV.
Granulomatous Mastitis (GM) is an uncommon form of mastitis frequently associated with autoimmune diseases. This entity requires a differential diagnosis with breast tumor and infections and may be treated with glucocorticoids and metho-trexate.
To analyze the relationship between cytokines and clinical manifestations of Respiratory Syncytial Virus (RSV) infection and to investigate the clinical value of cytokines in RSV pneumonia. Clinical data of RSV positive children admitted to the pediatrics department of Zhengzhou People's Hospital from November 2021 to June 2023.
Penile squаmous cell cаrcinomа is а rаre mаlignаncy аnd secondаry mаlignаncies to the penis аre extremely rаre аnd represent а unique chаllenge for urologists. We report а cаse of аn 80-yeаr-old pаtient with 3-month pаinful priаpism from locаlly аdvаnced prostаte аdenocаrcinomа
This study aims to explore the changes in the patient spectrum and the challenges and practices in nursing brought about by the evolution of modern hand surgery patients and medical development. A retrospective study was conducted on clinical data from 21,512 hand surgery patients in our hospital over the past 15 years. The study examined changes in patient spectrum, shifts in patient demands, evolutions in nursing models, and variations in patient satisfaction.
The predominant explanation of male homophobia, for lay persons and professionals alike, is a Freudian reaction formation against one's own repressed or suppressed homoerotic desires. Instead, the primary motivation for homophobic behavior by men and boys is avoiding social shaming and maintaining social acceptance.
The efficiency of mRNA vaccines in COVID-19 prevention has been successfully approved and has been awarded by Nobel prize. However, more potential of such therapeutic approach has not been revealed yet. Developing mRNA vaccines for Hepatocellular Carcinoma (HCC) treatment holds immense potential and significance.
Coping, an essential intermediary variable of psychological stress, may affect the process of disease, and alongside family function, has also been linked to patient quality of life. However, these have not yet been investigated in older adults with hypertension. To investigate the correlation between medical coping modes and family function, and the associated factors among older adults with hypertension in China.
Intracranial Atherosclerosis (ICAS) is a common cerebrovascular lesion worldwide and an important cause of stroke [1]. Non-modifiable risk factors include age, gender, and genetics, with age being a key factor and atherosclerosis usually progressive, with no clinical manifestations until middle age.
Introduction: Brucellosis-Related Spondylodiscitis (BSD) presents diagnostic and therapeutic challenges due to nonspecific clinical signs, delayed appearance of radiological findings, and the lack of precise therapeutic consensus. This study aimed to determine the epidemiological, clinical, biological, radiological, therapeutic, and outcome characteristics of BSD.
The 2004 World Health Organization (WHO) classification of endocrine tumours defines phaeochromocytoma as a catecholamine-producing intra-adrenal tumour arising from the chromaffin cells. The most important functional characteristics of the adrenal and extra-adrenal sympathetic tissue derived tumours is the production of various types of catecholamines and the related clinical attributes [1].
Background: While vertebroplasty is a well-known technique for management of osteoporotic vertebral fractures, significant incidence of refracture and re-collapse can occur after vertebroplasty, which may necessitate a revision surgery in such weak bone conditions.
The aim of this study was to evaluate the clinical and radiographic outcomes of the All-on-4 technique in fully edentu-lous maxilla using R2GATE software for flapless, computer-guided surgery and immediate loading. Ten adult patients with fully edentulous maxilla, aged between 35 and 60 years, were included in the study between April 2021 and April 2022.
We wish to present a very unusual case of a toddler girl who presented with acute abdomen and features of peritonitis. Inflammatory markers were high but tumor markers were all within normal limits. The plain abdominal radiograph indicated suspicious small free air under the dome of diaphragm.
Background: Despite the implementation of various maternal health programs and schemes at both regional and national levels in Pakistan, maternal mortalities and morbidity remain significantly high. This suggests that maternal health services are being underutilized.
Beauty industry produces each year about 120 billion of packaging'units, 60% of which are made by plastic materials, invading the oceans as waste microparticles, toxic for animals and humans. Moreover, a great quantity of water is used to produce emulsions and solutions used as cosmetic carriers. Our research group are proposing smart patented non-woven tissues as alternative carriers for innovative medical devices, cosmeceuticals and nutraceuticals, reporting their main characteristics.
Human reproductive health is an integral part of personal well-being that can markedly impact upon individuals, couples, families and the wider society. It is estimated that infertility affects 13 to 15% of the world's population and with parents often deciding to delay planning for pregnancy until later in life, age-related concerns about the viability of female oocytes, in particular, are at the forefront of in vitro fertilisation (IVF) research.