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High levels of low-density lipoprotein and cholesterol in the blood have been associated with the development of atherosclerosis. Synthetic forms of sex hormones found in the combined oral contraceptive pill are suspected to affect lipid metabolism.
Bruton tyrosine kinase inhibitors, such as ibrutinib, are medications that are actively used for Chronic Lymphocytic Leukemia (CLL) and several lymphomas. They work by inhibiting Bruton's tyrosine kinase therefore affecting B cell proliferation. Ibrutinib itself is associated with multiple cardiotoxicities including atrial fibrillation, ventricular arrhythmias, heart failure, and bleeding.
Neurodevelopmental disorders are a group of clinical and genetic heterogeneous diseases characterized by impaired brain development, affecting personal, social, academic, or occupational functioning. Next-Generation Sequencing advent has allowed to unravel new diagnosis and improved knowledge of the molecular mechanism's underlying pathogenesis.
A 53-year-old female was presented to the emergency department with a 5-day history of chest distress and anhelation, who was a worker in a textile factory with a clear long-time exposure of asbestos for nearly 20 years. Both CT and ultrasound imaging showed the bilateral thoracic effusion and massive pericardial effusion.
A large spectrum of congenital cardiac malformations can be the consequence of deficient formation of the embryonic atrioventricular canal by the endocardial cushions [1]. Among them, together with bicuspid aortic valve and mitral valve prolapse (MVP) [2], atrial septal defects (ASD) are one of the most frequent congenital heart diseases in adulthood.
Hypertrophic Cardiomyopathy (HCM) is an inherited heart condition characterized by Left Ventricular (LV) wall thickening due to genetic mutations. It can lead to LV outflow tract obstruction, myocardial ischemia, mitral regurgitation, and diastolic dysfunction. A subset, Hypertrophic Obstructive Cardiomyopathy (HOCM), is more prevalent than previously thought.
Consequences of COVID-19 vaccination partly overlap with symptoms of post-COVID-19 syndrome. Putative mechanisms are also overlapping: endothelial damage and hyper coagulation, hypoxia, autoimmunity, inflammation, downregulation of angiotensin-converting enzyme. It can be reasonably assumed that effects of viral spike protein, observed in COVID-19, would to some extent appear also after administration of vaccines containing spike protein or inducing its synthesis.
Limited cutaneous systemic sclerosis also known as CREST syndrome - represents a limited form of systemic sclerosis, and although cardiac involvement is common in systemic sclerosis, it is extremely rare in the limited form [1]. The reported case describes a patient who developed an autoimmune myocarditis, with progression to cardiogenic shock, requiring a multidisciplinary approach in both cardiac and rheumatological diagnosis and treatment.