SciBase Cardiology

Research Article

Utility of a Wireless Ambulatory Monitoring System for Arrhythmic Event Detection in Pediatric Patients

Fernando Centeno-Malfaz*; Carlos Alcalde-Martín; Beatriz Salamanza-Zarzuela

Detection of arrhythmias in asymptomatic patients or with intermittent clinics represent a diagnostic challenge, being the traditional 24-hour monitoring systems, with low diagnostic performance. The Nuubo® system is one of the new wireless ambulatory monitoring systems (SMAI), which allows recording cardiac activity for up to 30 days.

Case Report

Surgical Management of Type A Aortic Dissection During the Second Trimester: A Case Report

Zhenqing Z*

A 29-year-old pregnant woman was referred to our center at gestational week 21 because of "sudden onset of chest pain for 15 hours"; she experienced retrosternal tearing pain with no radiation, accompanied by vomiting for three times, and the pain had no relief. Ultrasonography revealed aortic root dilatation with aortic regurgitation.

Research Article

Does Early Life Stress by Heart Failure Cause Short Stature, Learning Disabilities and Increase Later Cardiovascular Risk in Children with Congenital Heart Disease? Could we prevent it with Propranolol Treatment in Early Infancy?

Buchhorn R*; Willaschek C

Infants have the highest risk to die from heart failure, one of the most stressful life events in infancy. Moreover, this early life stress may have an impact on growth, neurodevelopment and later cardiovascular risk according the Developmental origins of health and disease (abbreviated DOHaD) approach.

Letter to the Editor

The Role of Beta-Adrenergic Receptor on Epinephrine induced Metastasis in Breast Cancer

Ali Hassan*; Hamna Ibrar

I am writing this letter to bring your concern on "The role of beta-adrenergic receptor on epinephrine-induced metastasis in breast cancer". Breast cancer is one of the most common cancers that affect women globally. Metastasis is a major factor in the morbidity and mortality of breast cancer.

Case Report

Effect of Alcohol on Heart: A Patient with Alcoholic Cardiomyopathy and Holiday Heart Syndrome

Christian Toquica; Quang Dat Ha*; Ramneek Sandhu; Prami Nakarmi; Bhavin Patel

Alcohol use has been linked to the development of cardiac arrhythmias and non-ischemic dilated cardiomyopathy. We describe a case of a 29-year-old male who presented with palpitations and chest pain after binge drinking alcohol. We report the clinical presentation, investigations and outcomes after 6 months of abstinence from alcohol.

Research Article

Transforming Marfan Syndrome Diagnosis with AI and Federated Learning

Venkatesh Upadrista*; Stefan Schulze

Marfan Syndrome is a genetic disorder affecting connective tissue, leading to severe cardiovascular, skeletal, and ocular complications. Early detection is essential to prevent critical outcomes such as aortic aneurysms and dissections. However, traditional diagnostic methods, including advanced imaging and genetic testing, are often expensive and invasive.

Case Report

Polymicrobial Infective Endocarditis with Stroke in a Patient with Metastatic Colorectal Cancer

Emmanuel Ukenenye*; Nikola Stojanović; Alexa Kahn; Bisrat Nigussie; David Gunsburg; Abdullah Khan

A rare instance of infective endocarditis by Streptococcus viridans and Lactobacillus spp in an elderly patient with advanced colorectal cancer, leading to an aortic valve abscess, infectious emboli, and stroke. Our hypothesis is the gastrointestinal tract served as the probable entry route for the bacteria.

Clinical Image

Pulmonary Hypertension Secondary to Pulmonary Artery Branch Stenosis in a 2-Year-Old Infant

Zhen Bing*; Rui Chen

The patient admitted to the hospital is a 2-year-old girl with cyanosis. The SPO2 is about 87% (in-room air) across all four limbs. Echocardiography showed Atrial Septal Defect (ASD, 17 mm, Panel A, arrow), ventricular septal defect (VSD, 8.5 mm, Panel B, arrow), and severe pulmonary hypertension (Panel C).

Short Commentary

Translation of Electrocardiography and Genetics in Arrhythmogenic Left Ventricular Cardiomyopathy

Stefan Peters*

Translational cardiology combines different techniques in order to get a correct diagnosis (precision medicine). In a rare disease called arrhythmogenic left ventricular cardiomyopathy caused by non-desmosonal gene mutations 12-lead ECG and results of genetics were combined and analyzed.

Research Article

Effect of Combined Oral Contraceptive Pills on Established Biomarkers of Lipid Metabolism: Systematic Review and Meta-Analysis

Amazon Doble*; Nicola King

High levels of low-density lipoprotein and cholesterol in the blood have been associated with the development of atherosclerosis. Synthetic forms of sex hormones found in the combined oral contraceptive pill are suspected to affect lipid metabolism.

Case Series

Advanced Cardiac Conduction Abnormalities in Patients on Ibrutinib Therapy

Romil Patel*; Charlie Robin; Jason Robin

Bruton tyrosine kinase inhibitors, such as ibrutinib, are medications that are actively used for Chronic Lymphocytic Leukemia (CLL) and several lymphomas. They work by inhibiting Bruton's tyrosine kinase therefore affecting B cell proliferation. Ibrutinib itself is associated with multiple cardiotoxicities including atrial fibrillation, ventricular arrhythmias, heart failure, and bleeding.

Case Report

Homozygous Variant on CLASP2 Gene Associated to Intellectual Disability and Rhythm Disorder

Susana Lemos Ferreira; João Parente Freixo; Pedro Silva Cunha; Diana Oliveira Antunes

Neurodevelopmental disorders are a group of clinical and genetic heterogeneous diseases characterized by impaired brain development, affecting personal, social, academic, or occupational functioning. Next-Generation Sequencing advent has allowed to unravel new diagnosis and improved knowledge of the molecular mechanism's underlying pathogenesis.

Case Report

Multiple Malignant Pericardial Mesothelioma Presenting with Massive Hemorrhagic Pericardial Effusion Diagnosed by PET-CT and Pathological Tests: A Case Report

Lei Huang; Jiacheng Rong*

A 53-year-old female was presented to the emergency department with a 5-day history of chest distress and anhelation, who was a worker in a textile factory with a clear long-time exposure of asbestos for nearly 20 years. Both CT and ultrasound imaging showed the bilateral thoracic effusion and massive pericardial effusion.

Short Report

Large Ostium Primum Interatrial Septum Defect in Asymptomatic Adult Athlete with Mitral Valve Prolapse and New Onset of Atrial Fibrillation

Colella A*; Crescenzi C; Tatangelo M; Calò L

A large spectrum of congenital cardiac malformations can be the consequence of deficient formation of the embryonic atrioventricular canal by the endocardial cushions [1]. Among them, together with bicuspid aortic valve and mitral valve prolapse (MVP) [2], atrial septal defects (ASD) are one of the most frequent congenital heart diseases in adulthood.

Case Report

Enhancing the Diagnosis of Hypertrophic Cardiomyopathy Diagnosis: A Case of Integrating Cardiac Magnetic Resonance Imaging

Azeem Rathore, DO*; Ali El-Husari, BS; Mohammad Ibrahim, BS; Daanish Khawaja; Niyati Patel, DO; Rafik Jacob, MD

Hypertrophic Cardiomyopathy (HCM) is an inherited heart condition characterized by Left Ventricular (LV) wall thickening due to genetic mutations. It can lead to LV outflow tract obstruction, myocardial ischemia, mitral regurgitation, and diastolic dysfunction. A subset, Hypertrophic Obstructive Cardiomyopathy (HOCM), is more prevalent than previously thought.

Review Article

Post-COVID-19 Syndrome vs. Consequences of Vaccination with Special Reference to Cardiovascular Conditions

Hans-Bernd Bludau; Sergei V Jargin*

Consequences of COVID-19 vaccination partly overlap with symptoms of post-COVID-19 syndrome. Putative mechanisms are also overlapping: endothelial damage and hyper coagulation, hypoxia, autoimmunity, inflammation, downregulation of angiotensin-converting enzyme. It can be reasonably assumed that effects of viral spike protein, observed in COVID-19, would to some extent appear also after administration of vaccines containing spike protein or inducing its synthesis.

Case Report

Myocardial Involvement in CREST Syndrome: A Case Report of a Rare Myocarditis' Etiology

Simão Carvalho*; Ana Sofia Azevedo; Adriana Pacheco; Diana Carvalho; Carlos Costa; Tiago Aguiar; Joana Ribeiro; Ana Catarina Faustino; Raquel Ferreira; Andreia Fernandes; Anabela Barcelos; Ana Neves; José Mesquita Bastos

Limited cutaneous systemic sclerosis also known as CREST syndrome - represents a limited form of systemic sclerosis, and although cardiac involvement is common in systemic sclerosis, it is extremely rare in the limited form [1]. The reported case describes a patient who developed an autoimmune myocarditis, with progression to cardiogenic shock, requiring a multidisciplinary approach in both cardiac and rheumatological diagnosis and treatment.