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Numerous microbial communities reside in the human body, and it is feasible to consider the microbiota that resides in our gastrointestinal tract and other anatomical locations as a component of the environment to which we are continuously exposed at high doses throughout our lifespan [1-5].
Hematopoietic Stem Cell Transplantation (HSCT) is considered a curative option for children with Acute Myeloid Leukemia (AML). Post-HSCT relapse in pediatric AML is associated with poor outcomes. Our ability to predict this event is limited. Chimerism analysis can be followed sequentially to detect Mixed Chimerism (MC) trends to identify the risk of relapse.
Curcumin, a golden-yellow flavonoid derived from turmeric, has been used in traditional Chinese and Indian medicine for centuries due to its antioxidant and anti-inflammatory properties. Recent interest has grown in its potential therapeutic applications in cancer research.
Glioblastoma is the most common and aggressive primary brain tumor in adults. It is characterized by its highly invasive nature and resistance to current treatment strategies. The microenvironment of glioblastoma plays a crucial role in tumor progression and therapeutic resistance.
In our efforts to extend the possible application of highly cytotoxic maytansine derivatives as a payload in drug delivery systems, we found that thiol group in 9-thioansamitocib P3 could be successfully used to create a disulfide linker to the carrier.
Metastatic femoral neck fractures in the elderly population are typically managed with cemented hip hemiarthroplasty. With the paucity of similar studies, this study aims to review the clinical outcomes of uncemented hip hemiarthroplasty.
We tried to investigate any discriminatory attitudes towards elderly people through the administration of questionnaires to all healthcare workers in 10 radiotherapy oncology departments in the regions of Puglia and Basilicata. Some ageist attitudes have emerged; not as discriminatory acts but as the result of archaic, unconscious and stereotyped conceptions. The age problem is mainly due to false information that causes misconceptions about the elderly.
Benign Prostatic Hyperplasia (BPH) is one of the most common benign diseases in middle-aged and elderly men, characterized by lower urinary tract symptoms such as urinary frequency, urgency, and weak urine flow, which can lead to complications such as urinary retention and incontinence. Traditional Chinese Medicine (TCM) has a long history and rich experience in treating BPH, with herbal formulas widely used in clinical practice due to their significant efficacy and safety.
Prostate cancer is the most common form of non-skin cancer in men and the second leading cause of cancer death among them. The estimated incidence of prostate cancer worldwide was 1,414,259 in 2020, making it the fourth most commonly diagnosed malignancy, with the majority of cases seen in those over 65 years of age.
Vibrational Optical Coherence Tomography (VOCT) is a new technique to noninvasively characterize skin cancers. We have previously shown that skin cancers exhibit new mechanovibrational peaks at 80, 130, and 250-260 Hz.
To reveal the memories of elderly people about living with the Human Immunodeficiency Virus. Cross-sectional study, with a descriptive analytical character, a qualitative approach and theoretical-methodological support for the Theory of Collective Memory and the Theory of Social Representations. Carried out with 38 seniors.
Cancer treatment is an area of ongoing concern and requires a great deal of research in order to provide patients and providers with the best possible therapeutic options. Conventional chemotherapeutic agents typically cause serious, unexpected side effects from the harmful consequences of the agents on normal, noncancerous tissues.
Ovarian cancer is the most fatal gynecological cancer worldwide. Oftentimes, the management is challenging in low and middle-income settings. This case demonstrates for the first time a papillary serous adenocarcinoma of the ovary seen in a nulliparous young lady in our hospital, coupled with its associated management challenges.
This study validates novel biological and health systems reliability method, in particular suitable for complex multi-dimensional public health and biological systems, versus the well-established bivariate bio-reliability method, being known to accurately assess bivariate dynamic system's extreme contours.
The widespread use of gold nanoparticles (AuNPs) in many fields has increased; however, their potential effects on embryofetal development have not been explored. This study was designed to investigate the potential effects of different sizes of gold nanoparticles (AuNPs) on maternal and embryo-fetal development in rats.
Rectal Adenocarcinoma (RA) represents more than 90% of rectal tumors, with high global incidence and mortality rates. Treatment includes neoadjuvant therapy, curative surgery, and postoperative adjuvant therapy. Complete Pathologic Response (CPR) signifies the absence of residual tumors and affected lymph nodes.
This work was designed to investigate the possible acute and long-term acute toxicity of intravenous (i.v.) injection of 50 nm gold nanorods (AuNRs) in dogs. Eighteen native dogs were divided into control (n=8); acute toxicity (n=5), and long-term acute toxicity (n=5).
This research expresses the preparation and investigation of methotrexate-loaded PLGA nanoparticles on Glioblastoma Multiforme (GBM). The nanoparticles were prepared by precipitation method which had a mean diameter of 102±5 nm with azeta potential of -26±2 mV. The methotrexate loading was 8.3%.
Cancer includes a broad group of diseases that are characterized by the uncontrolled growth of abnormal cells, which can affect any part of the organism, and according to the World Health Organization (WHO), is one of the leading causes of death worldwide. One of the hallmarks of cancer is the development of metastasis, the main cause of death in more than 90% of cancer patients.
Purpose: The objective of this study is to investigate the changes in CCNG1 and FDXR gene expression during RT in breast cancer patients and associate the observed changes with disease- and therapy-related confounding factors through a non-randomized, controlled, open-trial clinical study of 57 breast cancer patients.